Researchers say it will take years to develop "super" aspirin into a drug suitable for humans.
The new drug New York City College researchers wrote this month's "American Chemical Society Medicinal Chemistry Express" published a paper that this new type of aspirin can inhibit pancreatic cancer, lung cancer, colon cancer, breast cancer, prostate cancer, leukemia, etc. Eleven malignant tumor cells grow without damaging normal cells.
This “super†aspirin is called nitric oxide*hydrogen peroxide (NOSH) aspirin, a mixture of two previously developed aspirin derivatives, one that releases nitric oxide to help protect the gastric mucosa, and the other The release of *H2O enhances the anticancer capacity of aspirin.
The researchers found that the two derivatives were safer to mix than either one; alone, the mixture was 15,000 times stronger than nitric oxide aspirin and 80 times stronger than H2O2 aspirin in terms of anticancer efficacy.
This means that drugs developed on the basis of this mixture require less doses to exert sufficient action and reduce potential side effects.
The potent non-toxic researchers found that the efficacy of nitric oxide, aspirin, on cancer cells in culture dishes was 100,000 times stronger than normal aspirin after 24 hours and about 250,000 times stronger after 72 hours.
In the second experiment, the researchers allowed the mice to carry human colon cancer and let them take oral nitric oxide aspirin. As a result, the cancer cells self-disappeared and the tumor shrank by 85%, which effectively inhibited the proliferation of cancer cells and significantly delayed tumor growth. No toxic side effects on rats.
The EurekAlert website sponsored by the American Association for the Advancement of Science quoted the head of research as Horslow Kashmir, an associate professor at the City College of New York, as saying: "The main ingredient of this new mixture is very, very effective, and it has very little (normal) cytotoxicity."
Still have to wait for Kashfi to say: "If the (effect) we see in animals can be transferred to humans, it can be used with other drugs to shrink the tumor before chemotherapy or surgical resection."
Karshoff wrote in the research report that they will conduct toxic and side effects tests and clinical trials in the next step in order to develop drugs suitable for humans. “Super†aspirin will remain on the market for several years.
Previous studies have shown that long-term use of aspirin reduces the risk of colon cancer by an average of 50% over those who do not use it, but may have serious side effects such as internal hemorrhage, ulcers, and renal failure.
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